Purineless death as a link between growth rate and cytotoxicity by methotrexate.
نویسنده
چکیده
cause the suppression. Hypoxanthine completely prevented these biochemical effects of MIX and partially protected the cells against its lethal effects. Thus, in the murine S-phase lymphoblasts, MTX produces a purineless state, the degree of which depends upon the growth rate of the population. The purineless state probably contributes to the lethal effect of MTX, and this may partly explain the relation between growth rate and cytotoxicity by antifolates.
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عنوان ژورنال:
- Cancer research
دوره 32 7 شماره
صفحات -
تاریخ انتشار 1972